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Lipoxygenases in Inflammation ebook

Lipoxygenases in Inflammation ebook

Lipoxygenases in Inflammation. Dieter Steinhilber

Lipoxygenases in Inflammation
ISBN: 9783319277646 | 245 pages | 7 Mb

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Lipoxygenases in Inflammation Dieter Steinhilber
Publisher: Springer International Publishing

Inflammation and immune regulation by 12/15-lipoxygenases. Cardiac 12/15 lipoxygenase–induced inflammation is involved in heart . A number of elegant studies over the last thirty years have contributed to unraveling the role that lipoxygenases play in chronic inflammation. Minocycline inhibits 5-lipoxygenase activation and brain inflammation after focal cerebral ischemia in rats. 12/15- LOX induces inflammation that is involved in heart failure. OBJECTIVE: 12-Lipoxygenase (12-LO) induces inflammation and has been implicated in diabetes development. The 5-lipoxygenase (5-LOX) Inhibitor Zileuton Reduces Inflammation and Infarct Size with Improvement in Neurological Outcome Following Cerebral Ischemia. Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent- neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve. Arachidonate 12/15-Lipoxygenase–Induced Inflammation and Oxidative Stress Are Involved in the Development of Diabetic Cardiomyopathy. Inhibition of 12/15-Lipoxygenase Reduces Renal Inflammation and Injury in Streptozotocin-Induced Diabetic Mice, Journal of Diabetes & Metabolism. 5-Lipoxygenase metabolites of arachidonic acid, the leukotrienes, play a role in these inflammatory processes. Reflecting these different functions are lipoxygenases with different characteristics in . Sonic hedgehog-responsive lipoxygenases and cyclooxygenase-2 modulate Dectin-1-induced inflammatory cytokines. Cancer and inflammation are intimately linked due to specific oxidative processes in the tumor microenvironment. In mammals, lipoxygenases play key roles in inflammation by initiating the transformation of lipoxygenase (LoxA) that converts arachidonic acid into 15-. However, the detailed mechanism of how 5-lipoxygenase regulates theinflammatory response in arthritis synovial tissue is still unclear. Insights into IgE-mediated lung inflammation derived from a study employing a 5-lipoxygenase inhibitor. Inhibition of 5-lipoxygenase and skin inflammation by the aerial parts of Artemisia capillaris and its constituents. Provoke bronchoconstriction and inflammation. The most important lipoxygenases are the 5-1ipoxygenases.

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